Spectrophotometric determination and estimation of minoxidil in tablet dosage form by UV

Authors

Khadeerunnisa S Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India. Author
VimalakKannan Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India. Author
Vijaya Lakshmi T Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India. Author

Keywords:

Minoxidil, 0.1N HCl, UV- spectroscopy, Validation

Abstract

A simple, precise, accurate and economical UV spectrophotometric method has been developed and validated for the estimation of Minoxidil in the tablet dosage form. Minoxidil shows maximum absorbance at 279.4nm. The method was carried out by using 0.1N HCl as a solvent. The drug shows linearity from the concentration range of 1-6µg/ml and correlation coefficient was found to be 0.9992. The proposed method was statistically validated for precision, accuracy, ruggedness, robustness, the limit of detection, quantitation as per the ICH guidelines. Hence this method can be successfully applied for routine analysis of Minoxidil in bulk and tablet dosage form.