Jellyfishes – A Promising Marine Resource for Wound Healing Application

Abstract

The medical community is very interested in the wound-healing process, which is impacted by both patient-specific and external factors. This review article's goal is to draw attention to the bio compounds—such as polysaccharide compounds, collagen, collagen peptides, and amino acids—found in jellyfish that have been shown to have the ability to heal wounds. Polysaccharides (JSPs) and collagen-based materials can help certain parts of the wound-healing process since they have been demonstrated to reduce bacterial exposure and encourage tissue regeneration. The immunostimulatory effects of bio compounds derived from jellyfish on growth factors important in wound healing, like TNF-α, IFN-γ, and TGF, constitute a second proven advantage. The antioxidant activity of collagens and polysaccharides (JSP) is a third advantage. Aspects related to chronic wound care are specifically addressed, and within this general theme, molecular pathways related to tissue regeneration are explored in depth. Only distinct varieties of jellyfish that are specifically enriched in the bio compounds involved in these pathways and live in European marine habitats are presented. The advantages of jellyfish collagens over mammalian collagens are highlighted by the fact that jellyfish collagens are not considered transmitters of diseases (spongiform encephalopathy) or various allergic reactions. Jellyfish collagen extracts stimulate an immune response in vivo without inducing allergic complications. More studies are needed to explore more varieties of jellyfish that can be exploited for their biocomponents, which may be useful in wound healing.